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Imbalances that may result from Mannitol Injection administration include: Hypernatremia, dehydration and hemoconcentration. Hyponatremia, which can lead to headache, nausea, seizures, lethargy, coma, cerebral edema, and death. Acute symptomatic hyponatremic encephalopathy is considered a medical emergency. Overview. Cerebral edema is excessive accumulation of fluid in the intracellular or extracellular spaces of the brain that increases pressure within the skull, leading to direct compression of the brain with impairment of function. Several neurologic disorders are associated with cerebral edema, particularly traumatic brain injury and large.

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